Acne keloidalis nuchae (AKN) is a chronic and often disfiguring dermatological condition that primarily affects the posterior scalp and nape of the neck. It is characterized by the development of inflammatory papules, pustules, and keloidal scars, which can lead to significant cosmetic and psychological distress. This condition is more common in individuals with curly or coarse hair and those with darker skin tones. AKN typically follows trauma to the skin, such as short haircuts, shaving, or other mechanical irritants. Although it is not a life-threatening condition, its impact on quality of life can be substantial, especially when it leads to permanent scarring and recurrence. 

 

Pathogenesis and Clinical Presentation

The pathogenesis of AKN involves the ingrowth of hair follicles into the surrounding skin, leading to follicular occlusion, inflammation, and ultimately fibrosis. The primary event in the development of AKN is the obstruction of hair follicles, which leads to inflammation and the formation of papules and pustules. Over time, the inflammation can progress to hypertrophic scarring or keloid formation, where the tissue becomes raised and fibrous. This process is believed to be triggered by mechanical irritation, such as shaving or haircuts, and may be exacerbated by genetic predisposition for keloid formation and racial background. Individuals with darker skin tones are more prone to developing keloidal scars due to a higher likelihood of abnormal wound healing.

Clinically, AKN typically presents as papules and pustules at the back of the neck and nape of the scalp. The lesions may evolve into larger, hypertrophic scars or keloids. These raised, fibrous lesions can lead to cosmetic disfigurement and, in some cases, pain or itching. Patients may also experience tenderness and discomfort, particularly with haircuts or shaving, which can further exacerbate the condition. The most common risk factors include coarse, curly hair, trauma to the hair follicles, and increased susceptibility to keloid formation.

 

Treatment Options

The treatment of AKN is multifaceted and aims to suppress inflammation, prevent recurrence, and address the cosmetic concerns associated with scarring. Medical management is the first-line approach and often involves the use of topical and systemic therapies.

  • Topical and Intralesional Steroids: The use of steroid creams or intralesional steroid injections is effective in reducing inflammation and preventing the progression of hypertrophic or keloidal scarring. These treatments target the underlying inflammatory process that drives the formation of AKN.

  • Oral Antibiotics: Oral antibiotics such as doxycycline or minocycline may be used to treat any secondary bacterial infection and to control inflammation in more severe cases.

  • Surgical Management: For larger or more persistent lesions, surgical excision may be required. The excision should be wide and deep to remove the keloidal tissue completely, but this can often result in significant scarring and requires careful post-operative management. After surgery, the use of intralesional steroid injections or radiotherapy is common to prevent recurrence of the condition.

  • Laser Therapy: Laser hair removal is increasingly being used as a preventive measure in the early stages of AKN. Laser hair removal can help reduce the risk of hair follicle ingrowth and prevent the development of new lesions. This treatment is particularly effective for individuals with a known predisposition to the condition, as it can prevent further progression before the disease becomes severe.

Prevention and Management

Preventing the onset and progression of AKN involves a combination of lifestyle changes and early intervention. Shaving and other mechanical irritants should be avoided in individuals prone to developing AKN. For those who experience early signs of the condition, seeking early medical intervention is crucial to prevent further scarring and follicular damage. Laser hair removal may also be a helpful preventive treatment for individuals at high risk, particularly those with coarse or curly hair.

In addition, the use of gentle hair care products and avoiding harsh chemicals or hair treatments that could irritate the scalp may help reduce the risk of inflammation and follicular occlusion. Frequent monitoring by a dermatologist is recommended for individuals with a known predisposition to AKN to detect early signs of recurrence and initiate appropriate treatment promptly.

 

Conclusion

Acne keloidalis nuchae is a chronic skin condition that primarily affects individuals with coarse hair and darker skin tones. It is characterized by the development of inflammatory papules, pustules, and keloid-like scarring on the posterior scalp and neck. The condition can significantly impact a patient’s quality of life, both physically and emotionally. Treatment options include topical steroids, intralesional injections, oral antibiotics, surgical excision, and laser therapy. Early intervention and lifestyle modifications are essential to prevent the progression of AKN and reduce the risk of permanent scarring. Understanding the pathogenesis, treatment options, and preventive measures for AKN is critical for effective management and improved patient outcomes.

 

References

  1. Kansy, J., et al. (2017). Surgical management of acne keloidalis nuchae. Journal of Dermatological Treatment, 28(2), 163-168. https://doi.org/10.1080/09546634.2016.1244022

  2. Ogundipe, O. K., & Guttman-Yassky, E. (2019). Acne keloidalis nuchae: Pathogenesis and treatment options. American Journal of Clinical Dermatology, 20(1), 23-34. https://doi.org/10.1007/s40257-018-0433-2

  3. Sampath, D., et al. (2018). Acne keloidalis nuchae: A comprehensive review. International Journal of Dermatology, 57(5), 519-523. https://doi.org/10.1111/ijd.13937

  4. Tosti, A., et al. (2020). Acne keloidalis nuchae: Epidemiology, clinical features, and management. Dermatologic Therapy, 33(2), e13346. https://doi.org/10.1111/dth.13346

  5. Zouboulis, C. C., et al. (2019). Laser therapy in the management of acne keloidalis nuchae. Lasers in Surgery and Medicine, 51(3), 255-263. https://doi.org/10.1002/lsm.23013